Cancer

Immune Therapy Takes A ‘BiTE’ Out Of Brain Cancer

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Investigators have created a new method that could make immune therapy more effective again brain tumors and expand its use against other types of solid tumors. Building on their research showing that an exciting new form of immunotherapy for cancer has activity in patients with glioblastoma, the most common and most deadly form of brain cancer, Massachusetts General Hospital (MGH) investigators have created a new method that could make immune therapy more effective again brain tumors and expand its use against other types of solid tumors. Their study is published in the journal Nature Biotechnology.

How Breast Cancer Uses Exosomes To Metastasize To The Brain

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In breast cancer, metastases to the brain often spell a death sentence; many women survive for less than a year after diagnosis. A new study reveals how the cancer is able to cross the blood-brain-barrier: by sending out exosomes that hijack the natural cell process of transcytosis, tricking the cells in the BBB into taking them up. Metastasizing breast cancers typically seek out the bones, lung, and brain. Brain metastases are especially dangerous; many women survive for less than a year after diagnosis. How is the cancer able to get past the blood brain barrier? And can it be blocked?